CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor EPZ004777

CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor EPZ004777 Descriptor: 1,2-ETHANEDIOL, 7-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]-5-deoxy-beta-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine, DNA Strand 1, ... Authors: Horton, J.R, Cheng, X, Zhou, J. Deposit date: 2021-07-14 Release date: 2021-09-15 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.68 Å) Cite: Repurposing epigenetic inhibitors to target the Clostridioides difficile- specific DNA adenine methyltransferase and sporulation regulator CamA. Epigenetics, 17, 2022CamA腺嘌呤甲基转移酶与同源底物DNA及抑制剂EPZ004777复合物 描述符：1,2-乙二醇、7-{5-[(3-{[(4-叔丁基苯基)氨基甲酰基]氨基}丙基)(异丙基)氨基]-5-脱氧-β-D-呋喃核糖基}-7H-吡咯并[2,3-d]嘧啶-4-胺、DNA链1，…… 作者：Horton, J.R.、Cheng, X.、Zhou, J. 提交日期：2021-07-14 发布日期：2021-09-15 最后修改日期：2023-10-18 实验方法：X射线衍射（分辨率2.68埃） 引用文献：《靶向艰难梭菌特异性DNA腺嘌呤甲基转移酶与孢子形成调节因子CamA的表观遗传抑制剂再利用》，《表观遗传学》，第17卷，2022年