Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and telithromycin at 2.60A resolution

Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and telithromycin at 2.60A resolution Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... Authors: Chen, C.-W, Syroegin, E.A, Svetlov, M.S, Polikanov, Y.S. Deposit date: 2022-12-01 Release date: 2023-07-12 Last modified: 2025-03-19 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural insights into the mechanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A. Nat Commun, 14, 2023

分辨率达2.60埃的嗜热栖热菌（Thermus thermophilus）70S核糖体与蛋白Y、潮霉素A（hygromycin A）及泰利霉素（telithromycin）复合物的晶体结构。描述项：(4S)-2-甲基-2,4-戊二醇、16S核糖体RNA、23S核糖体RNA等。作者：Chen, C.-W、Syroegin, E.A、Svetlov, M.S、Polikanov, Y.S。提交日期：2022-12-01；发布日期：2023-07-12；最后修改日期：2025-03-19。实验方法：X射线衍射（X-RAY DIFFRACTION，2.6 Å）。引用文献：《大环内酯类联合潮霉素A克服Erm介导耐药性的结构机制解析》，《自然-通讯》（Nat Commun），2023年，第14卷。