Crystal structure of SOS1 in complex with compound 8

Crystal structure of SOS1 in complex with compound 8 Descriptor: IMIDAZOLE, Son of sevenless homolog 1, ~{N}-[(1~{R})-1-[3-azanyl-5-(trifluoromethyl)phenyl]ethyl]-6,7-dimethoxy-2-methyl-quinazolin-4-amine Authors: Bader, G, Kessler, D, Wolkerstorfer, B. Deposit date: 2020-11-06 Release date: 2021-03-24 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.1 Å) Cite: One Atom Makes All the Difference: Getting a Foot in the Door between SOS1 and KRAS. J.Med.Chem., 64, 2021与化合物8结合的SOS1晶体结构。描述符：咪唑（IMIDAZOLE）、七上同系物1（Son of sevenless homolog 1），配体为N-[(1R)-1-[3-氨基-5-(三氟甲基)苯基]乙基]-6,7-二甲氧基-2-甲基-喹唑啉-4-胺。作者：Bader G、Kessler D、Wolkerstorfer B。沉积日期：2020-11-06。发布日期：2021-03-24。最后修改日期：2024-01-31。解析方法：X射线衍射（分辨率2.1埃）。引用文献：《One Atom Makes All the Difference: Getting a Foot in the Door between SOS1与KRAS》，载于《药物化学杂志》（J.Med.Chem.），2021年，第64卷。