Therapeutic goals mentioned in the studies.

a. TG was defined as “the therapeutic benefit that the intervention studied was intended to have for the patients”.b. Examples: “to assess the use of porphyrin fluorescence in malignant glioma after administration of 5-aminolevulinic acid for improving resection as defined by postoperative MRI, and to analyse the effect of resection on progression free survival, neurological morbidity, and type and frequency of treatment after progression” [25]; “Besides determining tumor response rate to LM/TMZ [lomeguatrib/temozolomide], we aimed to test whether the combination could produce tumor shrinkage in patients progressing on TMZ alone” [23].c. Examples: “to assess efficacy and tumor delivery of cilengitide in patients with recurrent GBM” [22]; “to define the activity of metronomic chemotherapy with either oral etoposide or temozolomide, combined with bevacizumab” [24].AA: anaplastic astrocytoma, GBM: glioblastoma, HRQoL: health-related quality of life, MRI: magnetic resonance imaging, TG: therapeutic goal.Therapeutic goals mentioned in the studies.