Additional file 7: of HER2 is not a cancer subtype but rather a pan-cancer event and is highly enriched in AR-driven breast tumors

Characterization of HER2E tumors and AR-ness signature. (A) Overview of genes differentially expressed between HER2E and non-HER2E TCGA tumors, accounting for ER expression, PR expression, and PAM50 proliferation score, and omitting genes on chromosome 17. (B) Gene set enrichment results for the C2 gene set collection from MSigDB [22] (KEGG gene sets were removed), for the comparison of HER2E versus non-HER2E TCGA tumors. (C) 45-gene AR-ness signature. (XLSX 6449 kb)