RNA-Seq, Sufficiently atrophied soleus and EDL muscle tissues of mice

To examine whole mRNA expression using RNA-Seq to determine the genes that show fluctuating expression levels in sufficiently atrophied soleus and EDL muscle tissues of mice. We found that atrophy of both muscles equilibrated 36 days after denervation. In this state, several up- or downregulated genes were newly detected in each muscle, and the commonly regulated genes were assumed to be related to a new set point that maintained skeletal muscle size in the atrophic state.