Small cell lung cancer

Small cell lung carcinoma (SCLC) is a highly malignant cancer of the lung. Genes altered in small cell lung carcinoma: * TP53 is mutated in 70-90% of SCLCs. * RB1 is inactivated in most SCLCs. * PTEN is mutated in 2-10% of SCLCs. * MYC amplifications and amplification of MYC family members is found in 30% of SCLCs. * FHIT protein expression is lost due to Loss of heterozygocity (LOH) on chromosome arm 3p found in more than 80% of SCLCs. This description was adapted from [https://en.wikipedia.org/wiki/Small-cell_carcinoma Wikipedia]. Phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org.小细胞肺癌（SCLC）是一种高度恶性的肺部肿瘤。小细胞肺癌中发生改变的基因包括：* TP53 基因在70-90%的小细胞肺癌中发生突变。* RB1 基因在大多数小细胞肺癌中失活。* PTEN 基因在2-10%的小细胞肺癌中发生突变。* MYC 基因扩增及其家族成员的扩增在小细胞肺癌中见于30%。* 由于3p染色体臂上的杂合性丢失（LOH）导致FHIT蛋白表达丧失，这种现象在超过80%的小细胞肺癌中观察到。本描述改编自[https://en.wikipedia.org/wiki/Small-cell_carcinoma Wikipedia]。根据PhosphoSitePlus（R）的信息，添加了磷酸化位点，www.phosphosite.org。

搜集汇总

背景与挑战

背景概述

该数据集聚焦于小细胞肺癌（SCLC），提供了详细的分子通路信息，包括TP53、RB1等关键基因的突变频率和信号通路参与者。它整合了基因产物、代谢物和通路注释，适用于癌症生物学研究和精准医疗分析。