Figure 7

Figure 7: Sympathetic and sensory nerves show similar structural associations in the adult human kidney. (A) Wholemount immunostained human kidney cortex labeled with podocin (yellow) and SMA (magenta) show interlobular arteries branching and glomerular organization (zoom 3D rendering). (B) Wholemount immunostained human kidney cortex labeled with TH (green) and SMA (magenta) showing sympathetic nerves branching with interlobar, arcuate, and interlobular arteries (arrowheads). (C) Adult human kidney cortical sections show PIEZO2 (magenta) overlapping with TUBB3 (green) and associating with glomeruli (podocalyxin, yellow; arrowhead, top panel) and the vasculature (podocalyxin, yellow; arrowhead, middle panel). PIEZO2+ sensory nerves were also observed near epithelial structures (LRP2, green; ECAD, yellow; arrowhead, bottom panel). (D) Adult human kidney cortical sections show SYN1+ axons (green) near glomeruli (podocalyxin, magenta; arrowhead, left panel) and epithelial structures (ECAD, yellow; arrowhead, right panel).