The RESILIENT SALMON project is about developing a more robust salmon that can better handle multi-stressor conditions by use of functional feeds combined with nutritional programming to induce trained immunity.

Resilient salmon project is a spin-off project to Foods of Norway, a Centre for research-based Innovation, where we develop bioactive components from microbial ingredients (e.g. yeast or filamentous fungi) or brown seaweed extracts from brown seaweed such as fucoidan for use in functional feeds. These are evaluated in the project with the aim to improve health and robustness of salmon during the stress-full period of seawater transfer. In vitro screening (WP1) and targeted delivery (WP2) of bioactive components selected in WP1. In vivo studies (WP3) of A) interactions between diets and fish family groups differing in robustness in fresh water and sea water (WP3.1), B) nutritional programming for improved immunity (WP3.2). Evaluation of the most promising treatment and nutritional program in an infection pathogen challenge trial (WP4). Samples collected from WP3 trials will be subjected to a wide range of host phenotyping (histopathology, immunophenotyping, transcriptomics, proteomics) and (WP5) metabolomics as well as metagenomics and metaproteomics of gut microbiota will be performed to reveal factors determining nutritional effects on salmon developmental biology, environmental requirements and coping strategies in the various life stages. In WP6 results will be disseminated and communicated to academia, industry, and society.