Effects of RYGB on liver health in obese mice.

We investigated the effects of RYGB compared to a sham surgery or caloric restriction on hepatic function. For that, the goals of this study is to identify changes in the liver transcriptome profiling (RNA-seq) that could explain improvements in liver health and function with RYGB compared to other treatment methods. Mice underwent RYGB bariatric surgery, sham surgery, or were weight-matched to the RYGB group via calorie restriction. Mice were euthanized 20 weeks post-surgery and liver tissue was collected.