The Integrator complex controls the termination of transcription at diverse classes of gene targets
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The Integrator complex controls the termination of transcription at diverse classes of gene targets
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2015-01-20
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The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts. The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts
Transcription by RNA polymerase II (RNAPII) is pervasive in the human genome. However, the mechanisms controlling transcription at promoters and enhancers remain enigmatic. Here, we demonstrate that I
NIAID Data Ecosystem70
INTS13 Mutations Causing a Developmental Ciliopathy Disrupt Integrator Complex Assembly
Oral-facial-digital syndromes (OFD) are a heterogeneous group of congenital disorders characterized by malformations of the face and oral cavity, and digit anomalies. To date, mutations in 12 ciliary-
NIAID Data Ecosystem40
RNAseq of Bacillus subtilis wildtype and cspB-cspD deletion mutant reveals that the lack of the cold shock proteins CspB and CspD affects the expression of about 20% of all genes. RNAseq of Bacillus subtilis wildtype and cspB-cspD deletion mutant reveals that the lack of the cold shock proteins CspB and CspD affects the expression of about 20% of all genes
RNAseq of coding RNA in Bacillus subtilis wildtype and deletion strain GP1971 genotype trpC2 ΔcspB::cat ΔcspD::aphA3 using rRNA depleted mRNA and Illumina TruSeq stranded mRNA libraries, sequenced on
NIAID Data Ecosystem30
Pcf11/Spt5 condensates stall RNA polymerase II to facilitate termination and piRNA-guided heterochromatin formation
Pcf11/Spt5 condensates stall RNA polymerase II to facilitate termination and piRNA-guided heterochromatin formation
integrated proteome resources60
PP1 PNUTS binds the “restrictor” and dephosphorylates pol II CTD Ser5 to stimulate RNA pol II transcription termination [eNET-seq]
The restrictor complex, WDR82/ZC3H4, is the major termination factor for antisense transcription from bidirectional promoters, but its mechanism of action is poorly understood. We report that the PP1
NIAID Data Ecosystem30
