Cross-Dehydrogenative Coupling of Azoarenes with Dialkyl Disulfides

A catalyst-free cross-dehydrogenative
coupling reaction of purines
and some azoarenes with dialkyl disulfides has been developed. This
procedure provided a novel strategy to construct unsymmetrical disulfides
through the α-heterocyclic functionalization of symmetrical
dialkyl disulfides. The S–S bond was successfully tolerated
in this transformation. The mild conditions and the broad scope of
azoarenes indicated the potential application of this procedure.