Data for: Regulation of hyaluronan biosynthesis and clinical impact of excessive hyaluronan production

This review addresses the molecular mechanisms that regulate hyaluronan biosynthesis at both transcriptional and posttranslational levels, as well as the roles of hyaluronan deficiency or overproduction in various diseases, such as multiple myeloma, aggressive breast carcinomas, metabolic diseases and virus infection. Such knowledge may be use to devise methods for diagnosis or treatment of diseases.

本综述探讨了调节透明质酸生物合成的分子机制，该机制涉及转录和翻译后水平，并阐述了透明质酸缺乏或过度产生在多种疾病，如多发性骨髓瘤、侵袭性乳腺癌、代谢性疾病和病毒感染中的作用。此类知识或许有助于制定疾病诊断或治疗的方法。