Effect of Metformin on Biomarkers of Colorectal Tumor Cell Growth

The purpose of this study is to investigate the effects of short term oral Metformin therapy on biomarkers for tumor growth in subjects with newly diagnosed colon or rectal adenocarcinoma.
It is hypothesized that there are independent actions of Metformin on the outcome of subjects with colorectal cancer (CRC). Also hypothesized is that metformin effects on CRC cell growth will correlate with this drug’s effects on markers mentioned above, because the markers are closely related to tumor growth and metastases.