Potentially functional APA alleles are positively correlated with risk alleles from GWAS SNPs.
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Two predicates were tested in a binomial setting: for positive trend correlation between APA and risk alleles, and for the strength of the correlation. For the 60 APA-SNPs paired to GWAS-SNPs, the proportions of and were respectively and . Among the 9 SNPs identified in the previous sections as functional candidate, respectively 8 and 5 succeeded the Bernoulli trial. Both null hypotheses were rejected.
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2012-08-16
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