Gene expression profile of U2-OS control and NSD3 knockdown cells
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE118129
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资源简介：
Osteosarcomas (OS) have highly chaotic genomes, yet their cancer drivers are poorly defined. Leveraging cross-species OS genomics we identify the frequent amplification of NSD3, a histone lysine methyltransferase and expose the NSD3-ARID3A axis as a core pathway in osteosarcomagenesis. Loss- and gain-of-function studies with CRISPR-Cas9 and lentivirus systems establish the causal role of NSD3 in OS tumor growth and spontaneous metastasis. Expression microarrays are performed to study the mechanism of NSD3 on promoting OS progression
创建时间：
2021-08-04
