Analysis of all possible steering sequences of length one, two and three.

For each of the 15 antibiotics we calculated the probability evolution to the most resistant genotype to that drug when that drug is applied to a population first primed by a single, ordered pair or ordered triple of drugs. This table shows the number of priming singles, pairs and triples which improve or worsen the likelihood of evolution to that most highly resistant genotype. We allowed steering drugs to appear multiple times in the combination and also allowed the final drug to appear as a steering drug. In each case the initial population was given by μ = [1/2N,…,1/2N] and r = 0. As the SAM landscape is single-peaked no combination of steering drugs will improve or worsen the outcome. As such, we have computed the overall numbers both with and without the contribution of the SAM row.Analysis of all possible steering sequences of length one, two and three.