GWAS summary statistics for self-reported high cholesterol (UK Biobank Data-Field 20002; Coding 1473)
收藏资源简介:
GWAS summary statistics for self-reported high cholesterol in the UK Biobank (Data-Field 20002; Coding 1473), output by PLINK2 software. This includes: P-values for each SNP (three rows per SNP, ordered by additive test TEST = "ADD"; dominance test TEST = "DOMDEV" and the 2-df joint test TEST = "GENO_2DF"), obtained from the genotypic model where both additive and dominance effects are included (file: bri_result_high_chol.self_reported_cholesterol.glm.logistic.hybrid). and P-values for each SNP from the traditional additive test, where the model is additive-only (file: bri_result_high_chol_additive.self_reported_cholesterol.glm.logistic.hybrid). Please note that for the traditional additive GWAS result, one should refer to the second file, not to the first file (where TEST = "ADD"). Each variable (column) in the PLINK2 summary is interpreted as the following: #CHROM: The chromosome number. POS: GRCh37 position. ID: The SNP ID. REF: Reference Allele. ALT: Alternate Allele. A1: The Effect Allele. FIRTH?: Whether to use the Firth implementation for the logistic regression. TEST: Indication of the type of hypothesis test to perform ("GENO_2DF": joint test; "DOMDEV": dominance test; "ADD": additive test) OBS_CT: Number of samples included in the analysis. OR: Odds ratio. LOG(OR)_SE: Standard error of the log odds ratio. (first file) Z_OR_F_STAT: Wald Statistics for the 1-df test (TEST = "DOMDEV" or "ADD") and the 2-df test (TEST = "GENO_2DF"). (second file) Z_STAT: Z Statistics for the test. P: P-value for the test. ERRCODE: Error code ("." means no error).



