Benzotriazole as an Efficient Ligand in Cu-Catalyzed Glaser Reaction

Benzotriazole has been established
as an efficient ligand in Cu-catalyzed
cross-coupling of terminal alkynes to form 1,3-dialkynes using CuI
as the catalyst and K2CO3 as the base at room
temperature in an open round-bottom flask. The established protocol
has the following notable advantages: simple to handle, easy work-up,
mild reaction condition, high substrate scope, requirement of less
quantity of ligand and also Cu-catalyst, less expensive, and high
reaction yield.