CirGRDB

Although several databases have been built for circadian genes, a resource for comprehensive post-transcriptional regulatory information of circadian RNAs and expression patterns of disease-related circadian RNAs is still lacking. Here, we developed CirGRDB by integrating more than 4936 genome-wide assays, with the aim of fulfilling the growing need to understand the rhythms of life. CirGRDB presents a friendly web interface that allows users to search and browse temporal expression patterns of interested genes in 37 human/mouse tissues or cell lines, and three clinical disorders including sleep disorder, aging and tumor.

尽管目前已针对节律基因（circadian genes）构建了多个专用数据库，但仍缺乏可全面提供节律RNA转录后调控信息，以及疾病相关性节律RNA表达模式的整合资源。为此，我们整合了逾4936项全基因组检测实验数据，开发了CirGRDB数据库，以满足学界对生命节律研究日益增长的需求。CirGRDB配备友好的网页交互界面，支持用户检索并浏览37种人类/小鼠组织及细胞系中目标基因的时序表达谱，以及与睡眠障碍、衰老与肿瘤三类临床病症相关的节律RNA表达特征。

搜集汇总

背景与挑战

背景概述

CirGRDB是一个综合性昼夜节律RNA数据库，整合了4936个全基因组分析数据，提供人类/小鼠37种组织或细胞系及三种临床疾病中基因的时间表达模式查询功能。