GOLGI MANNOSIDASE II complex with (3R,4R,5R)-3,4-Dihydroxy-5-({[(1R)-2-hydroxy-1 phenylethyl]amino}methyl) methylpyrrolidin-2-one

GOLGI MANNOSIDASE II complex with (3R,4R,5R)-3,4-Dihydroxy-5-({[(1R)-2-hydroxy-1 phenylethyl]amino}methyl) methylpyrrolidin-2-one Descriptor: (3R,4R,5R)-3,4-dihydroxy-5-({[(1R)-2-hydroxy-1-phenylethyl]amino}methyl)-1-methylpyrrolidin-2-one, (4R)-2-METHYLPENTANE-2,4-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Kuntz, D.A, Rose, D.R, Hoffman, D. Deposit date: 2008-06-05 Release date: 2008-07-01 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.74 Å) Cite: Functionalized pyrrolidine inhibitors of human type II alpha-mannosidases as anti-cancer agents: optimizing the fit to the active site Bioorg.Med.Chem., 16, 2008

本数据集为高尔基甘露糖苷酶II（Golgi Mannosidase II）与配体(3R,4R,5R)-3,4-二羟基-5-({[(1R)-2-羟基-1-苯乙基]氨基}甲基)-1-甲基吡咯烷-2-酮的复合物。描述符包含：(3R,4R,5R)-3,4-二羟基-5-({[(1R)-2-羟基-1-苯乙基]氨基}甲基)-1-甲基吡咯烷-2-酮、(4R)-2-甲基戊烷-2,4-二醇、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖等。作者：Kuntz, D.A.、Rose, D.R.、Hoffman, D.；入库日期：2008-06-05；发布日期：2008-07-01；最后修改日期：2024-10-30；实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.74埃（Å）；引用文献：《靶向人Ⅱ型α-甘露糖苷酶的功能化吡咯烷类抑制剂作为抗癌剂：优化与活性位点的匹配》，发表于《Bioorg.Med.Chem.》2008年，第16卷。