Constraint-Aware Plausible H5N1 HA - NA Variant Universe for Evolutionary Surveillance

A computationally derived set of 66,672 evolutionarily plausible H5N1 hemagglutinin (HA) and neuraminidase (NA) genotype pairs, generated from 20,755 HA and 19,873 NA sequences via epistatic module-guided recombination. Includes 1,000 high-priority variants annotated for mammalian adaptation markers, polybasic cleavage sites, stalk deletions, and antiviral resistance. Designed for non-predictive, ethically compliant influenza surveillance and risk assessment. Study & Data Curation By: [e-mail]