Efficient Synthesis of α‑Quaternary α‑Hydroxy-β-amino Esters via Silyl Glyoxylate-Mediated Three-Component Reactions
收藏NIAID Data Ecosystem2026-03-08 收录
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An efficient method has been developed for the enantioselective synthesis of fully protected α-quaternary α-hydroxy-β-amino esters via the coupling of three components: aryl Grignard reagents (or methyllithium), silyl glyoxylate, and N-tert-butanesulfinyl imines. This protocol enables successive formation of two C–C bonds and two adjacent chiral carbons with high stereocontrol in a one-pot operation.
创建时间：
2016-02-18
