Clinical outcomes of high-risk cutaneous squamous cell carcinomas treated with Mohs micrographic surgery alone: an analysis of local recurrence, regional nodal metastases, progression-free survival, and disease.

Clinical outcomes of high-risk cutaneous squamous cell carcinomas treated with Mohs micrographic surgery alone: an analysis of local recurrence, regional nodal metastases, progression-free survival, and disease. Supplemental Table 1 Patient demographics and high-risk tumor characteristics Supplemental Table 2 Multivariate Cox regression analysis demonstrating hazard ratios for high-risk tumor characteristics and associations with poor clinical outcomes. Statistically significant findings are highlighted in yellow. Supplemental Table 3 High-risk features associated with poor outcomes are presented as multivariate Cox proportional hazards models. Tumor features correlating with poor outcomes included size > 2cm, poor differentiation, and perineural invasion. Importantly, multivariate analysis demonstrated that poor differentiation was statistically significant for an increased risk of all poor outcomes – LR, NM, DM, and DSD. Supplemental Table 4 10-year cumulative incidence comparisons of local recurrence, nodal metastases and disease-specific death for high risk cSCC, stratified by AJCC and BWH stages, with our cohort compared to standardized historic published controls仅采用莫氏显微手术（Mohs micrographic surgery）治疗的高危皮肤鳞状细胞癌的临床结局：局部复发、区域淋巴结转移、无进展生存期及疾病相关结局分析。 补充表1 患者人口统计学特征与高危肿瘤特征 补充表2 多因素Cox回归分析：明确高危肿瘤特征的风险比及其与不良临床结局的相关性，具有统计学意义的结果以黄色高亮标注。 补充表3 将与不良结局相关的高危特征以多因素Cox比例风险模型形式呈现。与不良结局相关的肿瘤特征包括肿瘤直径＞2cm、低分化及神经周围浸润。值得注意的是，多因素分析结果显示，低分化对于所有不良结局——局部复发（LR）、区域淋巴结转移（NM）、远处转移（DM）及疾病特异性死亡（DSD）的风险升高均具有统计学意义。 补充表4 按AJCC分期与BWH分期分层，比较高危皮肤鳞状细胞癌的局部复发、淋巴结转移及疾病特异性死亡的10年累积发生率，并将本研究队列与已发表的标准化历史对照队列进行对比。