Hippo signaling instructs ectopic but not normal organ growth [Liver YapTazKO+CCl4]. Hippo signaling instructs ectopic but not normal organ growth [Liver YapTazKO+CCl4]

We conditionally deleted Yap/Taz from hepatocytes prior to induction of acute injury by injection of liver toxin carbon tetrachloride (CCl4). Overall design: Differential gene expression analysis of samples of purified hepatocytes from Yap/Taz KO livers 48 hours after acute injury and corresponding control conditions: regenerating Yap/Taz KO hepatocytes (Yap/Taz KO + CCl4), regenerating control hepatocytes (ctrl + CCl4), uninjured Yap/Taz KO hepatocytes (Yap/Taz KO) and uninjured control hepatocytes (ctrl).