Dataset on Antimalaria Drug-drug Interactions in mice

This data was obtained from the study aimed at determining changes in parasitaemia and selected liver and kidney function parameters in NK 65 Plasmodium berghei passaged mice treated with oral coadministration of artemether lumefantrine with rifampicin, ciprofloxacin, erythromycin, caffeinated paracetamol, tea extract grapefruit juice and beer.
The data comprises of percentage parasitaemia on days 3, 6 and 9 determined by microscopy using thin blood smears taken from the tail of the mice on day 3 before treatment commenced and on days 6 and 9.
It also contains the alanine amino transferase (ALT) aspartate amino transferase (AST) activities, serum total and direct bilirubin, Urea and creatinine concentrations collected on day 9 and determined from optical density values.

本数据集源自一项旨在确定经口服联合给药双氢青蒿素与替卡西林、环丙沙星、红霉素、含咖啡因的扑热息痛、茶提取物、葡萄柚汁和啤酒处理后的NK 65伯氏疟原虫传代小鼠体内血细胞比容、选定肝脏和肾脏功能参数变化的研究。数据包括在第3、6和9天通过显微镜观察小鼠尾静脉血涂片所得的百分比血细胞比容，以及在第3天治疗开始前、第6天和第9天采集的丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）活性、血清总胆红素和直接胆红素、尿素和肌酐浓度，并从光密度值中得出。