Activated STAT3 positively regulates CEBPB transcription

STAT3, activated by IL6 signaling cascade, is necessary for CEBPB transcription, but direct binding of STAT3 to the CEBPB promoter has not been demonstrated (Niehof et al. 2001). As CEBPB activates IL6 transcription in response to oncogenic RAS signaling, and IL6 activates CEBPB transcription (Niehof et al. 2001, Kuilman et al. 2008, Lee et al. 2010), a positive feedback loop exists between CEBPB and IL6.

STAT3（信号转导和转录激活因子3）在IL6信号级联反应的激活下，对于CEBPB（C/EBPβ）转录至关重要，然而，STAT3与CEBPB启动子直接结合的证据尚未得到证实（Niehof等，2001）。由于CEBPB在肿瘤基因RAS信号的作用下激活IL6的转录，而IL6又激活CEBPB的转录（Niehof等，2001，Kuilman等，2008，Lee等，2010），因此CEBPB与IL6之间形成了一个正向反馈回路。