GluN1:GluN2B (GRIN1:GRIN2B) di-heterotetramers bind LIN7:CASK:APBA1, DLG1 and KIF17

GluN1:GluN2B (GRIN1:GRIN2B) di-heteromers are transported to the plasma membrane from the endoplasmic reticulum (ER) via transport vesicles. At the membrane of transport vesicles, GluN1:GluN2B NMDA receptors associate with the complex of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1. The microtubule-associated kinesin motor protein KIF17 binds to the LIN7:CASK:APBA1 complex (Jo et al. 1999, Setou et al. 2000). During transport from ER to the plasma membrane, NMDA receptors are diverted from the somatic Golgi network and go through the dendritic ER subcompartment and dendritic Golgi instead. Besides CASK, interaction with DLG1 (SAP97) is required for GluN1:GluN2B NMDA receptors to go through this transport route (Jeyifous et al. 2009).

GluN1:GluN2B（GRIN1:GRIN2B）二聚体通过转运囊泡从内质网（ER）运输至质膜。在转运囊泡的膜上，GluN1:GluN2B NMDA受体与LIN7（LIN7A、LIN7B或LIN7C）、CASK和APBA1的复合物相连接。微管相关动力蛋白KIF17结合于LIN7:CASK:APBA1复合物（Jo 等，1999年，Setou 等，2000年）。在从内质网向质膜的运输过程中，NMDA受体被从体细胞高尔基网络转移，并穿过树突内质网亚室和树突高尔基。除CASK外，与DLG1（SAP97）的相互作用对于GluN1:GluN2B NMDA受体通过此运输途径是必需的（Jeyifous 等，2009年）。