Virological rebound times resulting from distinct virological removal.

The time to virological rebound depends on both the cost of resistance (‘selective disadvantage’, ) and the choice of drugs. Each table entry shows the time to virological rebound in [days] in an ensemble of hybrid stochastic deterministic simulations, where we assumed that the efficacy of the drugs against the wild type was . The drug was effective against an one-mutation strain and completely inefficient against the double-mutant. The fraction of non-infectious viruses () was set to one-third and the initial population was assumed to be all wild type. The viral load was said to be rebounded, if the viral load reached 90% of the pre-treatment viral load.