The interplay between effector and regulatory T (Treg) cells is crucial for adaptive immunity, but how Treg control effector cell flexibility is elusive. We found that the phosphatase PTEN links Treg
While much is known about the factors that promote diverse Treg cell responses, less is known about mechanisms that constrain Treg cells. Here we demonstrate phenotypic and transcriptional profiling
Neuroimmune crosstalk is critical for intestinal and tissue homeostasis. Yet the role of molecularly distinct subsets of gut-innervating neurons in regulating the activity of gut immunocytes, and the
Assess the impact of BATF deficiency on tissue Treg development, residency and phenotype. Conclusion: BATF deficiency limits maturation and activation of T cells regardless of location. Single color
Cullin-RING Ligases (CRLs), upon activation by neddylation, play the key roles in regulating many biological processes. However, how CRL-neddylation regulates the function of Treg cells remains elusiv
