Clinical, histopathologic and molecular features of idiopathic and diabetic nodular mesangial sclerosis in humans

Idiopathic nodular mesangial sclerosis, also called idiopathic nodular glomerulosclerosis (ING) is a rare clinical entity with unclear pathogenesis. The hallmark of this disease is the presence of nodular mesangial sclerosis on histology without clinical evidence of diabetes mellitus or other predisposing diagnoses. To achieve insights into its pathogenesis, we queried the clinical, histopathologic and transcriptomic features of ING and nodular diabetic nephropathy (DN) Overall design: Cross-sectional human kidney biopsies or nephrectomies embedded in OCT underwent laser microdissection of glomeruli and RNA was sequenced.