Aluminum-Catalyzed Enantio- and Diastereoselective Carbonyl Addition of Propargylsilanes. A New Approach to Enantioenriched Vinyl Epoxides
收藏NIAID Data Ecosystem2026-03-06 收录
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A new pathway involving a Lewis acid-catalyzed carbonyl addition reaction of propargylsilanes and its subsequent development into a general enantio- and diastereoselective process are described. Aliphatic propargylsilanes with both saturated and unsaturated sidechains were effective nucleophiles affording highly functionalized chiral vinyl epoxides in good enantioselectivities (85−94% ee), excellent diastereoselectivities (>99:1 E:Z; >99:1 anti:syn) and in moderate to good yields (49−97%).
创建时间：
2016-02-28
