Transcriptional characterization of mouse and rat ventral pallidum using single nucleus RNA-sequencing

The ventral pallidum (VP) was defined as a basal ganglia nucleus and a major output of the nucleus accumbens. It is known to be involved in motivated behaviors, including feeding. We sought to further characterize VP by sequencing the RNA from individual nuclei in mouse and rat VP and analyzing neuronal expression patterns. We also investigated the impact of a high-fat diet on VP transcription. These data will be useful for understanding cell type diversity in VP, homology between mouse and rat VP, and the impact of diet on VP gene expression.腹侧苍白球（ventral pallidum，VP）被定义为基底神经节核团，同时是伏隔核（nucleus accumbens）的主要输出核团。已知该核团参与包括摄食行为在内的动机性行为调控。本研究通过对小鼠与大鼠腹侧苍白球的单个细胞核进行RNA测序，并分析神经元表达模式，以期进一步表征腹侧苍白球的特征。此外，本研究还探究了高脂饮食对腹侧苍白球转录过程的影响。本数据集将有助于解析腹侧苍白球的细胞类型多样性、小鼠与大鼠腹侧苍白球的同源性，以及饮食对腹侧苍白球基因表达的调控效应。