Tissue damage signals repurpose NF-κB, AP-1 and Smad3 to direct a Rev-erb sensitive wound healing program in macrophages

A complex damage signal promotes co-localization of NFκB and Smad3 at Rev-erb-sensitive enhancers and drives expression of genes characteristic of alternate polarization states in the same cells. Chromatin mark H3K27Ac, transcription factors PU.1, cFos, SMAD3, and p65 were assessed by ChIP-Seq and RNA-Seq was used to measure gene expression in C57BL/6 and ReverbDKO mice and in in-vivo wounds