mRNA vaccination in octogenarian nuns 15 and 20 months after recovery from COVID-19 elicits robust immune and antibody responses that include Omicron

Immune transcriptome, antibody repertoire, anti-IgG and neutralizing antibody levels to SARS-CoV-2 spike protein and cytokine levels in 16 nuns (median 81 years) that had received the BNT162b2 mRNA vaccine 15 and 20 months after recovering from COVID-19 and in 5 previously infected nuns (median 86 years) that had received two doses 10 months after their infection in comparison to 14 naïve persons (median 58 years) and 5 naïve nuns (median 73 years) receiving two doses.

本研究收集了16位（中位年龄81岁）在感染COVID-19后恢复15个月和20个月接受BNT162b2 mRNA疫苗的修女群体的免疫转录组、抗体库、针对SARS-CoV-2刺突蛋白的IgG抗体和中和抗体水平，以及细胞因子水平；同时，与5位（中位年龄86岁）在感染后10个月接种两剂疫苗的既往感染修女群体进行比较；此外，还与14位（中位年龄58岁）和5位（中位年龄73岁）未接种过疫苗的 naive 个体以及5位未接种疫苗的 naive 修女群体进行了对比。