Crystal Structure of the first bromodomain of human BRD4 in complex with a benzo-triazepine ligand (BzT-7)

Crystal Structure of the first bromodomain of human BRD4 in complex with a benzo-triazepine ligand (BzT-7) Descriptor: 1,2-ETHANEDIOL, 8-chloro-1,4-dimethyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,3,4]benzotriazepine, Bromodomain-containing protein 4 Authors: Filippakopoulos, P, Picaud, S, Felletar, I, Fedorov, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Bracher, F, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2011-10-11 Release date: 2011-11-23 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.39 Å) Cite: Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family. Bioorg.Med.Chem., 20, 2012

人类BRD4首个溴结构域（bromodomain）与苯并三氮杂䓬配体（BzT-7）结合的晶体结构。描述物：1,2-乙二醇（1,2-ETHANEDIOL）、8-氯-1,4-二甲基-6-苯基-4H-[1,2,4]三唑并[4,3-a][1,3,4]苯并三氮杂䓬。含溴结构域蛋白4（Bromodomain-containing protein 4）。作者：Filippakopoulos, P、Picaud, S、Felletar, I、Fedorov, O、von Delft, F、Arrowsmith, C.H、Edwards, A.M、Weigelt, J、Bountra, C、Bracher, F、Knapp, S，以及结构基因组学联合会（Structural Genomics Consortium, SGC）。提交日期：2011-10-11，发布日期：2011-11-23，最后修改日期：2023-09-13。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.39埃（Å）。引用文献：《靶向BET家族溴结构域的苯并二氮杂䓬与苯并三氮杂䓬类蛋白相互作用抑制剂》，《Bioorg.Med.Chem.》，第20卷，2012年。