Linoleic acid metabolism affected by SARS-CoV-2

Lipid metabolism alternations that are related to infection by corona viruses. The information comes from the Yan et al. in 2019 in the bibliography, particularly Figure 5. That paper uses the HCoV-229E virus as a model. Note that that is different from the virus that causes the 2020 pandemic SARS-CoV-2. Fig 5 is in turn taken from https://www.kegg.jp/kegg-bin/show_pathway?map00591, which is a very simplified pathway, omitting several steps. The paper mentions that after virus infection many of the metabolites in his figure are increased in concentration. Interestingly, exogenous supplement of LA or AA in HCoV-229E-infected cells significantly suppressed HCoV-229E virus replication and this also happened in MERS-CoV.

与冠状病毒感染相关的脂质代谢变化。该信息来源于2019年Yan等人的文献，特别是图5。该论文以HCoV-229E病毒为模型进行研究。值得注意的是，此病毒与导致2020年大流行的SARS-CoV-2病毒不同。图5进一步来源于https://www.kegg.jp/kegg-bin/show_pathway?map00591，这是一个极为简化的途径图，省略了多个步骤。论文指出，病毒感染后，图中许多代谢物浓度均有所上升。有趣的是，在HCoV-229E感染细胞中外源性补充LA（亚油酸）或AA（α-亚麻酸）显著抑制了HCoV-229E病毒的复制，此效应亦在MERS-CoV中观察到。