Trypanothione reductase in complex with 4-(((3-(8-(2-((1R,2S,5R)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)ethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)propyl)(methyl)amino)methyl)-4-hydroxypiperidine-1-carboximidamide

Trypanothione reductase in complex with 4-(((3-(8-(2-((1R,2S,5R)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)ethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)propyl)(methyl)amino)methyl)-4-hydroxypiperidine-1-carboximidamide Descriptor: 4-(((3-(8-(2-((1R,2S,5R)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)ethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)propyl)(methyl)amino)methyl)-4-hydroxypiperidine-1-carboximidamide, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... Authors: Ilari, A, Fiorillo, A, Battista, T, Mocci, S. Deposit date: 2019-04-09 Release date: 2020-05-13 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.977 Å) Cite: Spiro-containing derivatives show antiparasitic activity against Trypanosoma brucei through inhibition of the trypanothione reductase enzyme. Plos Negl Trop Dis, 14, 2020

与4-(((3-(8-(2-((1R,2S,5R)-6,6-二甲基双环[3.1.1]庚烷-2-基)乙基)-4-氧代-1-苯基-1,3,8-三氮杂螺[4.5]癸烷-3-基)丙基)(甲基)氨基)甲基)-4-羟基哌啶-1-甲脒结合的锥硫氧还蛋白还原酶（Trypanothione reductase）
描述：4-(((3-(8-(2-((1R,2S,5R)-6,6-二甲基双环[3.1.1]庚烷-2-基)乙基)-4-氧代-1-苯基-1,3,8-三氮杂螺[4.5]癸烷-3-基)丙基)(甲基)氨基)甲基)-4-羟基哌啶-1-甲脒、黄素腺嘌呤二核苷酸（FLAVIN-ADENINE DINUCLEOTIDE）、甘油（GLYCEROL）等
作者：Ilari, A、Fiorillo, A、Battista, T、Mocci, S
提交日期：2019-04-09
发布日期：2020-05-13
最后修改日期：2024-10-23
实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.977 Å）
引用：含螺环结构的衍生物通过抑制锥硫氧还蛋白还原酶，展现出抗布氏锥虫（Trypanosoma brucei）的抗寄生活性。《PLOS被忽视的热带病》（Plos Negl Trop Dis），2020年，第14卷。