BrainSeq - Neurogenomics to Drive Novel Target Discovery for Neuropsychiatric Disorders

This ambitious project seeks to characterize the genetic and epigenetic regulation of multiple facets of transcription in distinct brain regions across the human lifespan in samples of major neuropsychiatric disorders and controls. Initially focused on schizophrenia and mood disorders, the goal of this consortium is to elucidate the underlying molecular mechanisms of genetic associations with the goal of identifying novel therapeutic targets. The consortium currently consists of seven pharmaceutical companies and a not-for-profit medical research institution working as a precompetitive team to...

本极具雄心的研究项目旨在针对主要神经精神疾病患者与健康对照的样本，解析人类全生命周期内不同脑区中转录过程多个维度的遗传调控与表观遗传调控（epigenetic regulation）机制。本项目初期聚焦精神分裂症与心境障碍，该研究联盟的核心目标为阐明遗传关联背后的潜在分子机制，进而发掘全新的治疗靶点。目前，该联盟由7家制药企业与1家非营利性医学研究机构组成，以竞争前合作团队的模式开展工作……