Acid-Mediated N–H/α,β-C(sp<sup>3</sup>)–H Trifunctionalization of Pyrrolidine: Intermolecular [3 + 2] Cycloaddition for the Construction of 2,3-Dihydro‑1<i>H</i>‑Pyrrolizine Derivatives
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A one-pot acid-mediated reaction has been developed for the N–H/α,β-C(sp3)–H trifunctionalization of pyrrolidine without any metallic reagents or external oxidants. This reaction involves the intermolecular [3 + 2] cycloaddition of in situ-generated azomethine ylides with acrylic esters to provide facile access to 2,3-dihydro-1H-pyrrolizine derivatives in high yields under mild conditions.
创建时间：
2016-08-01
