Chidamide used in MM primary cells [RNA-seq]

Most patients with multiple myeloma (MM) will eventually relapse and current treatments have limited effect. Herein, we demonstrate that succinate dehydrogenase subunitA (SDHA) was low expressed in MM patients, and patients with SDHA relatively high expression had long overall survival and progression-free survival. Furthermore, SDHA high expression inhibited proliferation and invasion in multiple myeloma (MM) cell lines and enhanced the anti-tumor and synergistic effect of chemotherapeutics. We conducted transcriptome comparison of BMMCs of three MM patients treated with DMSO or chidamide. Overall design: RNA-Seq profiles for BMMCs of three initial MM patients treated with DMSO. RNA-Seq profiles for BMMCs of three initial MM patients treated with chidamide.