Red hybrid tilapia (Oreochromis sp.) hindgut RNA-seq data after oral vaccination with a feed-based bivalent vaccine

Previous studies have proven that red hybrid tilapia (Oreochromis sp.) vaccinated with a feed-based bivalent vaccine incorporating the formalin-killed whole organisms Streptococcus agalactiae and Aeromonas hydrophila mixed with 10% palm oil showed good protection against streptococcosis and aeromoniasis diseases. However, the molecular mechanisms related to the induction of fish’s immunological responses after vaccination are poorly investigated. Therefore, a transcriptomic study using the hindgut of red hybrid tilapia after vaccination was conducted, as the gut plays a role in antigen uptake and nutrient absorption. The transcriptome dataset has the potential to provide an understanding of the early induction of immunological responses in red hybrid tilapia after vaccination. Here, the vaccinated and control red hybrid tilapia’s hindgut RNA-seq dataset was presented, which are available in the National Center for Biotechnology Information (NCBI) database with accession number PRJNA1014699.已有研究证实，经添加10%棕榈油、搭载福尔马林灭活全菌体无乳链球菌（Streptococcus agalactiae）与嗜水气单胞菌（Aeromonas hydrophila）的饲用二价疫苗免疫的红杂交罗非鱼（Oreochromis sp.），可对链球菌病与气单胞菌病产生良好防护效果。然而，目前针对疫苗免疫后鱼类免疫应答诱导相关的分子机制研究仍较为匮乏。鉴于肠道在抗原摄取与营养吸收过程中发挥重要作用，本研究针对免疫后红杂交罗非鱼的后肠组织开展转录组学分析。本转录组数据集有望阐明红杂交罗非鱼疫苗免疫后免疫应答的早期诱导机制。本研究公开了免疫组与对照组红杂交罗非鱼的后肠RNA测序（RNA-seq）数据集，该数据集已上传至美国国家生物技术信息中心（NCBI）数据库，登录号为PRJNA1014699。