Co-complex structure of bovine trypsin with a modified Bowman-Birk inhibitor (PtA)SFTI-1(1,14), that was 1,4-disubstituted with a 1,2,3- trizol to mimic a trans amide bond

Co-complex structure of bovine trypsin with a modified Bowman-Birk inhibitor (PtA)SFTI-1(1,14), that was 1,4-disubstituted with a 1,2,3- trizol to mimic a trans amide bond Descriptor: CALCIUM ION, CATIONIC TRYPSIN, DIMETHYLFORMAMIDE, ... Authors: Schmelz, S, Empting, M, Tischler, M, Nasu, D, Heinz, D, Kolmar, H. Deposit date: 2011-12-08 Release date: 2012-03-07 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Braces for the Peptide Backbone: Insights Into Structure-Activity Relation-Ships of Protease Inhibitor Mimics with Locked Amide Conformations Angew.Chem.Int.Ed.Engl., 51, 2012

牛胰蛋白酶（bovine trypsin）与经修饰的Bowman-Birk抑制剂（Bowman-Birk inhibitor）PtA（即SFTI-1(1,14)）的共晶复合物结构，该抑制剂通过1,4-二取代1,2,3-三唑（1,2,3-triazole）模拟反式酰胺键。描述符：钙离子、阳离子胰蛋白酶、二甲基甲酰胺等。作者：Schmelz S、Empting M、Tischler M、Nasu D、Heinz D、Kolmar H。沉积日期：2011-12-08，发布日期：2012-03-07，最后修改日期：2024-11-13。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.55埃。引用文献：《为肽骨架提供支撑：酰胺构象锁定的蛋白酶抑制剂模拟物的构效关系研究》，Angew.Chem.Int.Ed.Engl.，第51卷，2012年。