Reactive cytokine/chemokine expression in SH-SY5Y (SY) neurons and glia co-cultured for 5 days in the presence of <i>Bb</i> or L-OspA.

Microglia (μG) and aggregate cells (Agg), which contain astrocytes and microglia, produce higher concentrations of the inflammatory mediators assessed in response to Borrelia burgdorferi (Bb) as compared to astrocytes (A) or SY neuronal cells. Lipidated-outer surface protein A (L-OspA) was an important stimulant in this reaction. The growth factor VEGF, was expressed in neurons equally or more abundantly than glia in response to Bb. Aliquots of glial cell supernatant were all obtained from a single representative animal during an individual experiment. Values listed are in ng/ml except for *CCL3 which is in pg/ml, followed by a standard error of the mean where n = 2.