Additional file 14 of Candidate methylation sites associated with endocrine therapy resistance in ER+/HER2- breast cancer

Additional file 14. CpGs with concordant significant changes in the survival and resistance acquisition signatures and with significant correlation between paired DNA methylation and gene expression profiles. CpGs in single-locus (Additional File 4) and multi-locus (Additional File 7) survival signatures were selected according to three additional criteria: (i) CpG DNA methylation is significantly (adjusted p-value < 0.05) (anti-)correlated with expression of the nearby gene(s), (ii) CpG is also significantly differentially methylated (adjusted p-value < 0.05) in the corresponding RA signature at month 7 versus WT, (iii) CpG changes concordantly in survival and corresponding RA signature, that is, risk increasing loci are hypermethylated and risk decreasing loci are hypomethylated.