Human and rodent cell susceptibility and response to different orthohantaviruses uncovers various levels of cellular restriction

This study highlighted the complexity of host/virus relationship, showed that viruses are restricted at different levels of the viral cycle, and provided multiple levels of analysis to understand how these viruses differ in their interactions with cells to escape innate immunity, depending on the tissue and host origin Total RNA was extracted from 4 independent biological replicates of bank vole cells upon infection with PUUV or PHVs and non infected (12 samples).