SNP Allocation For Estimating Heritability (SAFE-<i>h</i>²): A tool to explore genomic origins of phenotypes for estimation of SNP heritability using additive-only allelic effects or additive and non-additive allelic effects

SAFE-<i>h</i>²is developed under an academic research study to provide proper estimates of SNP heritability. For this, SAFE-<i>h</i>²creates heritability profiles to prevent SNPs with illogical negative contributions to heritability. It also minimizes the contributions by false-positive SNP hits. Finally, SAFE-<i>h</i>² can perform a joint analysis on both additive and non-additive allelic effects. Therefore, it also provides the chance for GWASs to perform linear association tests while capturing both additive and non-additive effects.<b>Software Availability:</b> SAFE-<i>h</i>²(SNP Allocation For Estimating Heritability)<b> </b>contains the compiled SAFE-<i>h</i>² scripts with related installation and usage manual (Download link: https://github.com/SAFE-h2/SAFE-h2).Read the related research article “<b>SNP Allocation For Estimating Heritability (SAFE-</b><b><i>h</i></b>^{<strong>2</strong>}<b>): A tool to explore genomic origins of phenotypes for estimation of SNP heritability using additive-only allelic effects or additive and non-additive allelic effects” (doi:</b> https://doi.org/10.1101/2023.08.28.555092<b>)</b> for the full study and descriptions.<b>Citation: </b><i>Behrooz Darbani, Mogens Nicolaisen. </i>SNP Allocation For Estimating Heritability (SAFE-<i>h</i>²): A tool to explore genomic origins of phenotypes for estimation of SNP heritability using additive-only allelic effects or additive and non-additive allelic effects. doi: https://doi.org/10.1101/2023.08.28.555092<b>Contact: [e-mail], [e-mail]</b>Department of Agroecology, Faculty of Technical Sciences, Aarhus University, Slagelse, DenmarkSAFE-h²（SNP Allocation For Estimating Heritability，单核苷酸多态性遗传力估算分配工具）是一项学术研究中开发的工具，旨在精准估算单核苷酸多态性（Single Nucleotide Polymorphism, SNP）遗传力。为此，该工具生成遗传力特征谱，以避免出现对遗传力产生不合逻辑负贡献的SNP，同时最小化假阳性SNP命中带来的影响。此外，SAFE-h²支持对加性与非加性等位基因效应开展联合分析，因此可为全基因组关联研究（Genome-Wide Association Study, GWAS）在捕获加性与非加性效应的同时开展线性关联检验提供支撑。 【软件获取】SAFE-h²包含编译完成的SAFE-h²脚本及配套的安装与使用说明手册（下载链接：https://github.com/SAFE-h2/SAFE-h2）。 如需了解完整的研究内容与细节，请阅读相关研究论文：《单核苷酸多态性遗传力估算分配工具（SAFE-h²）：基于仅加性等位基因效应或加性与非加性等位基因效应探究表型的基因组起源以估算SNP遗传力》（DOI：https://doi.org/10.1101/2023.08.28.555092）。 【引用格式】Behrooz Darbani、Mogens Nicolaisen. 单核苷酸多态性遗传力估算分配工具（SAFE-h²）：基于仅加性等位基因效应或加性与非加性等位基因效应探究表型的基因组起源以估算SNP遗传力. DOI：https://doi.org/10.1101/2023.08.28.555092 【联系方式】[e-mail]、[e-mail]；丹麦奥胡斯大学技术学院农业生态系，斯拉厄尔瑟市。