DNA Methylation Analysis of the Rheumatoid arthritis using Reduced representation bisulfite sequencing

To investigate possible contributions of DNA epigenome-wide association study in RA, we used reduced representation bisulfite sequencing (RRBS) to detect the DNA methylation in between 5 RA patients and 5 healthy controls, and generated the genomic CG, CHG and CHH contexts (H=A, T or C) methylation patterns.