ECT2 promotes proliferation and metastasis of esophageal squamous cell carcinoma（ESCC） via Rho-ERK-VEGF/MMP9 signaling pathway

In order to analyze the difference in the whole gene expression profile of ESCC(esophageal squamous cell carcinoma) and normal adjecent esophageal tissue as well as cancer metastasis tissue. We found that ECT2 (Epithelial cell transformation sequence 2) is highly expressed in esophageal squamous cell carcinoma compared with adjacent normal tissues by microarray analysis, and we further analyzed the expression of ECT2 in 40 patients by qRT-PCR, and found that ECT2 is indeed high in cancer tissues. Expressed in normal tissues adjacent to cancer. We first confirmed the overexpression of ECT2 in ESCC, further confirming the signaling pathway in the oncogenisis of ESCC. 3 ESCC (esophageal squamous cell carcinoma) patients' ESCC tissues, adjacent normal tissues, and cancer metastasis tissues were obtained by surgery, and the whole genome (lncRNA and mRNA) microarray analysis was performed.