Behavioral and autonomic dynamics during propofol-induced unconsciousness

During general anesthesia, both behavioral and autonomic changes are caused by the administration of anesthetics such as propofol. Propofol produces unconsciousness by creating highly structured oscillations in brain circuits. The anesthetic also has autonomic effects due to its actions as a vasodilator and myocardial depressant. Understanding how autonomic dynamics change in relation to propofol-induced unconsciousness is an important scientific and clinical question since anesthesiologists often infer changes in level of unconsciousness from changes in autonomic dynamics.

Therefore, we present a dataset combining physiology-based indices for heart rate variability and electrodermal activity with a robust statistical tool to compare behavioral and multimodal autonomic changes before, during, and after propofol-induced unconsciousness. This dataset was recorded from nine healthy volunteers during computer-controlled administration of propofol. 

在全身麻醉过程中，由于丙泊酚等麻醉剂的施用，会导致行为和自主神经系统的变化。丙泊酚通过在脑回路中产生高度结构的振荡来产生无意识状态。该麻醉剂由于其作为血管扩张剂和心肌抑制剂的药理作用，也具有自主神经效应。了解自主神经动力学如何与丙泊酚诱导的无意识状态相关联，是一个重要的科学和临床问题，因为麻醉师通常会从自主神经动力学的变化中推断出无意识程度的改变。因此，我们呈现了一个数据集，该数据集结合了基于生理的心率变异性指数和皮肤电活动指数，并配备了一种稳健的统计工具，以比较在丙泊酚诱导的无意识状态之前、期间和之后的行为和多模态自主神经变化。该数据集是在丙泊酚计算机控制施用期间从九名健康志愿者中记录的。